A local moment approach to the degenerate Anderson impurity model

The local moment approach is extended to the orbitally-degenerate [SU(2N)] Anderson impurity model (AIM). Single-particle dynamics are obtained over the full range of energy scales, focussing here on particle-hole symmetry in the strongly correlated regime where the onsite Coulomb interaction leads to many-body Kondo physics with entangled spin and orbital degrees of freedom. The approach captures many-body broadening of the Hubbard satellites, recovers the correct exponential vanishing of the Kondo scale for all N, and its universal scaling spectra are found to be in very good agreement with numerical renormalization group (NRG) results. In particular the high-frequency logarithmic decays of the scaling spectra, obtained here in closed form for arbitrary N, coincide essentially perfectly with available numerics from the NRG. A particular case of an anisotropic Coulomb interaction, in which the model represents a system of N `capacitively-coupled' SU(2) AIMs, is also discussed. Here the model is generally characterised by two low-energy scales, the crossover between which is seen directly in its dynamics.Comment: 23 pages, 7 figure

Discourse Framing Educational Policy in the Quasi-Public Sphere: The Case of the Atlanta Beltline Tax Allocation District

This qualitative case study considered discourse used to frame and advance neoliberal policies affecting education. The unit of analysis was the renegotiations for The Atlanta Beltline Tax Allocation District (TAD) during the years 2013-2016. In this arrangement, Atlanta Public Schools agreed to forgo their portion of increases in property taxes for 25 years to fund the BeltLine redevelopment in exchange for annual payments. The Beltline is a 22-mile loop around Atlanta to increase transportation, green-space, and neighborhood revitalization. A quasi-private corporation (Atlanta BeltLine, Inc.) manages this publicly funded project. When Atlanta BeltLine, Inc. failed to make the annual payments to Atlanta Public Schools in 2013, negotiations played out publicly, resulting in a new deal between the City of Atlanta, Invest Atlanta, and Atlanta Public Schools in 2016. Guided by critical discourse studies and critical policy analysis, I examined media articles and interviews with five policymakers to identify discursive frames used during the Beltline renegotiation. To situate discourse with actual policy outcomes, I used the State of Georgia’s Education Database to identify school demographic changes between 2012 and 2020. I considered what discourse revealed about (1) social practices around policy negotiation, (2) convergences, divergences, and tensions with accounts of policymakers involved, and (3) the extent that discursive representations aligned with policy outcomes. Findings included discursive frames representing feuding policymakers, highlighting the economic potential of the BeltLine as paramount, using education as a negotiation tactic, championing the power of partnership, and minimizing democratic participation in favor of behind-the-scenes negotiations. Policymaker discourse amplified the issues of unmet promises, displacement, and affordability within BeltLine neighborhoods, which was supported by evidence of increased gentrification in 3 schools along the BeltLine. However, discourse ultimately represented unwavering support for TADs. In all, findings indicated that increases in property tax revenue diverted from a generation of Atlanta Public Schools students will likely result in pricing low-income, primarily Black families out of several BeltLine neighborhoods. In considering whose odds the BeltLine TAD favored, I offer implications for policymakers, community members, and educational leaders, along with a proposed research agenda for critically examining TADs through an educational lens

Observations of cold dust in nearby elliptical galaxies

Spectral energy distribution (SED) analyses that include new millimeter to far-infrared (FIR) observations obtained with continuum instruments on the Nobeyama and James Clerk Maxwell Telescopes and the Infrared Space Observatory are presented for seven nearby (<45 Mpc) FIR-bright elliptical galaxies. These are analyzed together with archival FIR and shortwave radio data obtained from the NASA/IPAC Extragalactic Database (NED). The radio to infrared SEDs are best-fitted by power law plus graybody models of dust residing in the central galactic regions within a 2.4 kpc diameter and with temperatures between ~21 and 28 K, emissivity index simeq2, and masses from ~1.6 to 19 × 105 M☉. The emissivity index is consistent with dust constituting amorphous silicate and carbonaceous grains previously modeled for stellar-heated dust observed in the Galaxy and other nearby extragalactic sources. Using updated dust absorption coefficients for this type of dust, dust masses are estimated that are similar to those determined from earlier FIR data alone, even though the latter results implied hotter dust temperatures. Fluxes and masses that are consistent with the new FIR and submillimeter data are estimated for dust cooler than 20 K within the central galactic regions. Tighter physical constraints for such cold, diffuse dust (if it exists) with low surface brightness will need sensitive FIR to submillimeter observations with the Spitzer Space Telescope, SCUBA2, or ALMA

Interventions for preventing oral mucositis for patients with cancer receiving treatment

Background: Treatment of cancer with chemotherapy is becoming increasingly more effective but is associated with short and long-term side effects. Oral side effects remain a major source of illness despite the use of a variety of agents to prevent them. Objectives: To evaluate the effectiveness of oral (and topical) prophylactic agents for oral mucositis and oral candidiasis in patients with cancer (excluding head and neck cancer), compared with placebo or no treatment. Search Strategy: Computerised MEDLINE, EMBASE, CINAHL, CANCERLIT, the Cochrane Controlled Trials Register and the Cochrane Oral Health Group Specialist Register search up to July 1999. Reference lists from relevant articles were scanned and the authors of eligible studies were contacted to identify trials and obtain additional information. Selection Criteria: Studies were selected if they met the following criteria: design - random or quasi-random allocation of participants; participants - anyone with cancer receiving chemotherapy (excluding head and neck cancer); interventions - prophylactic agents prescribed to reduce oral conditions arising from cancer or its treatment; outcomes - mucositis and oral candidiasis. Data Collection and Analysis: Information regarding methods, participants, interventions and outcome measures and results were independently extracted, in duplicate, by two reviewers (JC &amp; HW). Specialist advice was sought to categorise interventions. Authors were contacted for details of randomisation and withdrawals and a quality assessment was carried out using the Jadad criteria (Jadad 1998). The Cochrane Oral Health Group statistical guidelines were followed and relative risk values calculated using random effects models where significant heterogeneity was detected (P &lt; 0.1). Main Results: Thirty-eight reports of trials were initially included. Two were duplicate reports and nine were excluded as there was no useable information. Of the 27 useable studies 14 had data for mucositis comprising 945 randomised patients and 15 included data for oral candidiasis with 1164 randomised patients. Of the eight prophylactic agents used for mucositis only one, ice chips, was effective (Relative risk 0.57, 95% CI 0.43 to 0.77, chi-square for heterogeneity = 0.26 (df = 1), p = 0.61). The NNT to prevent one extra case of mucositis over the baseline incidence using ice chips was 4 (95%CI: 3 to 7). The NNT for when the baseline incidence of mucositis in the population ranges from 50% to 80% are 5 to 4 respectively. There is evidence that antifungal agents which are partially or fully absorbed from the gastrointestinal tract prevent oral candidiasis and that the partially absorbed agents may be more effective than the fully absorbed agents. The RR for partially absorbed agents was 0.13 (95% CI 0.06 to 0.27, chi-square for heterogeneity = 5.3 (df = 3), P = 0. 15). The NNT to prevent one extra case of oral candidiasis over the baseline incidence using partially absorbed drugs was 3 (95% CI: 3 to 5). The NNT for when the baseline incidence of oral candidiasis in the population ranges from 30% to 70% are 4 to 2 respectively. The general reporting of RCT's was poor however the median Jadad score was acceptable and improved further when the authors provided additional information. The sensitivity analysis confirmed the findings for oral candidiasis. Reviewer's Conclusions: There is some evidence that ice chips prevent mucositis. None of the other prophylactic agents included in this review prevented mucositis. There is evidence that prophylactic use of antifungal agents which are absorbed or partially absorbed from the gastrointestinal tract reduce the clinical signs of oral candidiasis, and the partially absorbed drugs may be more effective. Future trials in this area should address the link between oral and general health including outcomes relevant to the patient. Collaboration between medical and dental teams is indicated.</p

Mfd Protects Against Oxidative Stress in Bacillus Subtilis Independently of its Canonical Function in DNA Repair

Background: Previous reports showed that mutagenesis in nutrient-limiting conditions is dependent on Mfd in Bacillus subtilis. Mfd initiates one type of transcription-coupled repair (TCR); this type of repair is known to target bulky lesions, like those associated with UV exposure. Interestingly, the roles of Mfd in repair of oxidative-promoted DNA damage and regulation of transcription differ. Here, we used a genetic approach to test whether Mfd protected B. subtilis from exposure to two different oxidants. Results: Wild-type cells survived tert-butyl hydroperoxide (t-BHP) exposure significantly better than Mfd-deficient cells. This protective effect was independent of UvrA, a component of the canonical TCR/nucleotide excision repair (NER) pathway. Further, our results suggest that Mfd and MutY, a DNA glycosylase that processes 8-oxoG DNA mismatches, work together to protect cells from lesions generated by oxidative damage. We also tested the role of Mfd in mutagenesis in starved cells exposed to t-BHP. In conditions of oxidative stress, Mfd and MutY may work together in the formation of mutations. Unexpectedly, Mfd increased survival when cells were exposed to the protein oxidant diamide. Under this type of oxidative stress, cells survival was not affected by MutY or UvrA. Conclusions: These results are significant because they show that Mfd mediates error-prone repair of DNA and protects cells against oxidation of proteins by affecting gene expression; Mfd deficiency resulted in increased gene expression of the OhrR repressor which controls the cellular response to organic peroxide exposure. These observations point to Mfd functioning beyond a DNA repair factor in cells experiencing oxidative stress

Variability in Crassulacean Acid Metabolism: A Survey of North Carolina Succulent Species

This is the publisher's version, also available electronically from: http://www.jstor.org/stable/10.2307/2474765.The correlation between succulence and Crassulacean acid metabolism (CAM) was investigated in 28 succulent species growing in various habitats throughout North Carolina. Three species (Opuntia compressa^ Agave virginica, and Tillandsia usneoides) exhibited diurnal fluctuations in tissue titratable acidity, nighttime uptake of 1 4C02 , and a high carbon isotope ratio (513C), all indicators of CAM. Seven species displayed one or two characteristics of CAM in situ yet yielded lower 513C values, indicating a partial or total restriction of atmospheric CO2 uptake to the C3 photosynthetic system: Yucca gloriosa, Sesuvium maritimum, Talinum terettfolium, Diamorpha smallii, Sedum pusillum, Sedum nevii, and Sedum telephioides. Several of these species were apparently capable of utilizing the CAM pathway to fix internal respiratory CO2. The results emphasize that one photosynthetic pathway does not characterize all succulents in North Carolina

Quand l'information échappe à ses créateurs : le cas de l'artificialisation des terres agricoles en Languedoc-Roussillon

International audienceThis article aims to describe how the quantification of a phenomenon in relation to a specific worldview spreads and is distorted. This project has been supported by a regional public authority in Languedoc-Roussillon (France), and consisted in the production of information so to quantify and qualify the farmland decrease due to urban sprawl. The paper is based on Latour's actor-network theory; it characterizes the process of enrolment, and the development of dissidences. Identifying contradictory logics and dissidences help questioning the complexity of ‘closing the black-box' regarding information production and of sensemaking between heterogeneous actants involved in a supposed-to-be public debate.Cet article vise à spécifier comment la quantification d'un phénomène fondée sur une certaine vision du monde se propage et se déforme. Ce projet a été porté par une direction déconcentrée de l'Etat soucieuse de l'emprise croissante du bâti sur les terres agricoles en Languedoc-Roussillon. Le cadre théorique mobilisé, la sociologie de la traduction, permet d'identifier les grandes étapes d'intéressement, d'enrôlement, ainsi que le développement de controverses. Les difficultés rencontrées interrogent sur la complexité de clôture de processus innovants s'agissant de production d'information et de co-construction de sens associant des actants hétérogènes impliqués dans des procédures de débat public

The seawater neodymium and lead isotope record of the final stages of Central American Seaway closure

Key Points: Seawater Nd and Pb isotope records for the Pliocene Caribbean and EEP Caribbean Nd isotope composition became more UNADW-like during the Pliocene Short term changes support link between CAS closure and strength of AMOC The shoaling and final closure of the Central American Seaway (CAS) resulted in a major change of the global ocean circulation and has been suggested as an essential driver for strengthening of Atlantic Meridional Overturning Circulation (AMOC). The exact timing of CAS closure is key to interpreting its importance. Here we present a reconstruction of deep and intermediate water Nd and Pb isotope compositions obtained from fossil fish teeth and the authigenic coatings of planktonic foraminifera in the eastern equatorial Pacific (ODP Site 1241) and the Caribbean (ODP Sites 998, 999 and 1000) covering the final stages of CAS closure between 5.6 and 2.2 Ma. The data for the Pacific site indicate no significant Atlantic/Caribbean influence over this entire period. The Caribbean sites show a continuous trend to less radiogenic Nd isotope compositions during the Pliocene, consistent with an enhancement of Upper North Atlantic Deep Water (UNADW) inflow and a strengthening of the AMOC. Superimposed onto this long-term trend, shorter-term changes of intermediate Caribbean Nd isotope signatures approached more UNADW-like values during intervals when published reconstructions of seawater salinity suggested complete closure of the CAS. The data imply that significant deep water exchange with the Pacific essentially stopped by 7 Ma and that shallow exchange, which still occurred at least periodically until approximately 2.5 Ma, may have been linked to the strength of the AMOC but did not have any direct effect on the intermediate and deep Caribbean Nd isotope signatures through mixing with Pacific waters

A subset of methylated CpG sites differentiate psoriatic from normal skin.

Psoriasis is a chronic inflammatory immune-mediated disorder affecting the skin and other organs including joints. Over 1,300 transcripts are altered in psoriatic involved skin compared with normal skin. However, to our knowledge, global epigenetic profiling of psoriatic skin is previously unreported. Here, we describe a genome-wide study of altered CpG methylation in psoriatic skin. We determined the methylation levels at 27,578 CpG sites in skin samples from individuals with psoriasis (12 involved, 8 uninvolved) and 10 unaffected individuals. CpG methylation of involved skin differed from normal skin at 1,108 sites. Twelve mapped to the epidermal differentiation complex, upstream or within genes that are highly upregulated in psoriasis. Hierarchical clustering of 50 of the top differentially methylated (DM) sites separated psoriatic from normal skin samples with uninvolved skin exhibiting intermediate methylation. CpG sites where methylation was correlated with gene expression are reported. Sites with inverse correlations between methylation and nearby gene expression include those of KYNU, OAS2, S100A12, and SERPINB3, whose strong transcriptional upregulation is an important discriminator of psoriasis. Pyrosequencing of bisulfite-treated DNA from skin biopsies at three DM loci confirmed earlier findings and revealed reversion of methylation levels toward the non-psoriatic state after 1 month of anti-TNF-α therapy

Impurity transport, turbulence transitions and intrinsic rotation in Alcator C-Mod plasmas

Linear and nonlinear gyrokinetic simulations are used to probe turbulent impurity transport in intrinsically rotating tokamak plasmas. For this simulation-based study, experimental input parameters are taken from a pair of ICRF heated Alcator C-Mod discharges exhibiting a change in the sign of the normalized toroidal rotation gradient at mid-radius (i.e. a change from hollow to peaked intrinsic rotation profiles). The simulations show that there is no change in the peaking of the calcium impurity between the plasmas with peaked and hollow rotation profiles, suggesting that the impurity transport and the shape of the rotation do not always change together. Furthermore, near mid-radius, r/a = 0.5 (normalized midplane minor radius), the linear and nonlinear gyrokinetic simulations exhibit no evidence of a transition from ion temperature gradient (ITG) to trapped electron mode dominance when the intrinsic rotation profile changes from peaked to hollow. Extensive nonlinear sensitivity analysis is performed, and there is no change in the ITG critical gradient or in the stiffness of ion heat transport with the change in the intrinsic toroidal rotation profile shape, which suggests that the shape of the rotation profile is not dominated by the ITG onset in these cases.United States. Department of Energy (contract DE-FC02-99ER54512-CMOD)United States. Department of Energy (Fusion Energy Postdoctoral Research Program